Synthesis of Benzoxazinones Sulphur Analogs and Their Application as Bioherbicides: 1.4-Benzothiazinones and 1.4-Benzoxathianones for Weed Control

Eight different compounds inspired by benzoxazinones were synthesized in one simple step with easy purification. These have a sulfur atom instead of the oxygen present benzoxazinones. Furthermore, new derivative obtained Rutkauskas–Beresnevicius reaction was synthesized. evaluated vitro to assess their phytotoxicity plant cells elongation wheat coleoptiles. The novel showed higher inhibition than and positive control, especially at concentrations (1000 300 μM). Benzoxazinones been described as histidine deacetylase inhibitors we therefore effect 1.4-benzothiazinones 1.4-benzoxathianones against HDA6, most important enzymes family, silico molecular docking dynamics. In studies Echinochloa crus-galli, Lolium rigidum Portulaca oleracea weeds gave interesting results growth roots for both monocots dicots. Specifically, more pronounced dicots, case common purslane, whose concentration 1000 μM similar that classical herbicide employed control. Higher when an aliphatic group C2 position 1.4-benzothiazinones.